Early Life Stage (ELS) Test
Detailed Description
Early Life Stage (ELS) tests are used as an alternative to traditional whole-animal testing methods for evaluating toxicity of chemicals. ELS for birds involve injection into the air cell of fertile eggs early in development and artificial incubation for several days at which point tissues are sampled for analysis. This biologically realistic alternative to currently available cell-based in vitro testing methods, allows the study of metabolic and multi-organ effects of the exposure.
Sources/Usage
Public Domain.
Related
Reducing Animal Use in Ecotoxicity Testing and Biomonitoring
The Department of the Interior (DOI) generates scientific information needed to support the conservation and management of the nation’s natural resources. This includes conducting ecotoxicological research and testing. These activities may involve the biomonitoring of contaminants in the environment, conducting environmental damage assessments (for example, after an oil spill), and analyzing new...
Related
Reducing Animal Use in Ecotoxicity Testing and Biomonitoring
The Department of the Interior (DOI) generates scientific information needed to support the conservation and management of the nation’s natural resources. This includes conducting ecotoxicological research and testing. These activities may involve the biomonitoring of contaminants in the environment, conducting environmental damage assessments (for example, after an oil spill), and analyzing new...