Since 1956 the Great Lakes Fishery Commission has been responsible for formulating and implementing a program to eradicate or control the sea lamprey in the Great Lakes. The U.S. Fish and Wildlife Service and the Sea Lamprey Control Centre of the Canadian Department of the Environment act as agents for the Commission in sea lamprey control. In the search for a selective lampricide that would control lampreys without destroying fish and other aquatic organisms, about 6,000 chemicals were tested at the Hammond Bay Biological Station of the U.S. Fish and Wildlife Service, largely during the mid 1950's. One compound, TFM, which is selectively toxic to sea lampreys was developed for field use. In 1963 Bayluscide was discovered to be extremely toxic to sea lampreys. Because Bayluscide is also very toxic to fish, being virtually nonselective between lampreys and rainbow trout, only 3% by weight can be added to TFM without losing the selective toxicity of TFM. Addition of small amounts of Bayluscide to TFM, however, effects substantial savings by greatly reducing the amount of TFM needed for effective treatment of lamprey populations. Since 1963 mixtures of TFM and Bayluscide have been used as a lampricide in tributaries of the Great Lakes by both the U.S. and Canadian governments.
