Geographic Information Systems (GIS) and the development of extensive geodatabases have become invaluable tools for addressing a variety of contemporary societal issues and for making predictions about the future. The United States-Mexico Geographic Information System (USMX-GIS) is based on fundamental datasets that are produced and/or approved by the national geography agencies of each country, the U.S. Geological Survey (USGS) and the Instituto Nacional de Estadistica Y Geografia (INEGI) of Mexico, and the International Boundary and Water Commission (IBWC). The data are available at various scales to allow both regional and local analysis. The USGS and the INEGI have an extensive history of collaboration for transboundary mapping including exchanging digital technology and developing methods for harmonizing seamless national level geospatial datasets for binational environmental monitoring, urban growth analysis, and other scientific applications.