This digital data release contains previously published contours of thickness values of 23 named geological horizons, ranging in age from Cambrian to Tertiary. In alphabetical order, these horizons are the Atokan, Chesterian, Cretaceous, Desmoinesian, Guadalupian, Jurassic, Kinderhookian, Leonardian, Lower Hunton, Meramecian, Missourian, Morrowan, Ochoan, Osagean, Simpson-Viola, Sylvan-Cason, Tertiary, Timbered Hills-Arbuckle, Triassic, Upper Hunton, Virgillian, Wolfcampian, and Woodford-Chatanooga. The thicknesses were published in plates in the back matter of the Sedimentary Cover – North American Craton: U.S. volume of the larger Geological Society of America’s Decade of North American Geology effort. This volume, edited by L.L. Sloss, contains efforts from many geologists. In particular, the Southern Midcontinent plates were generated by K.S. Johnson, T.W. Amsden, R.E. Denison, S.P. Dutton, A.G. Goldstein, B. Rascoe, Jr., P.K Sutherland, and D.M. Thompson. In these thickness contours, spanning almost the entirety of the Phanerozoic, changes in basin configuration, uplift of source terranes, and resultant continental-scale depositional patterns can be witnessed.