This dataset consists of a series of 1-kilometer rasters which provide a mapping of the estimated use of 101 agricultural pesticide compounds for the conterminous United States. Each compound is mapped annually for the years 2013 through 2017, thus there are 505 rasters posted (101 compounds x 5 years). The datasets were created by taking previously-published county-level estimates of kilograms of agricultural pesticide use, then allocating them to agricultural pixels from the 2016 National Land Cover Database, aggregated to 1-kilometer spatial resolution.