The U.S. Geological Survey is conducting a regional water-resources investigation of the Gulf Costal Plain, which includes all of the Mississippi Alluvial Plain of southeastern Missouri, locally known as the southeast lowlands. The purpose of the regional study is to describe and evaluate the major aquifer systems in sediments of Tertiary and younger age in parts of 10 states (Grubb, 1984). In the southeast lowlands of Missouri, the sub-surface stratigraphy and structural configuration of geologic units need to be described in detail to define the major aquifer syustems in the area. The purpose of this report is to describe the subsurface geologic framework for Paleozoic, Mesozoic, and Cenozoic units in the southeast lowlands of Missouri and to correlate these units to those in adjecent States using geophysical and geologic methods (index map). Geophysical logs of wells were used to determine which units are aquifers or confining beds. The drilling of the U.S. Geological Survey test well 1-X in New Madrid County, Missouri, and the subsequent interpretation of geohydrologic data from the well have provided valuable information used in the preparation of this report.