A strategy for selecting Landsat 7 ETM+ imagery for development of a new generation national land cover database of the United States has been developed. This strategy is formulated to target Landsat 7 ETM+ scenes based on land cover and land use, vegetation phenology and image quality (cloudiness, haze). Criteria based on phenology and scene quality provide a national baseline for acquiring Landsat 7 data. Optimal time periods for discriminating land cover types were identified for each Landsat 7 path-row footprint and each proposed land cover mapping zone (mosaic of several path-rows based on landscape and ecoregion), from which three Landsat scenes were selected. This database of selected scenes is used to guide Landsat 7 data purchasing. This methodology provides a consistent framework for populating Landsat 7 imagery to be used for a new national land cover characterization initiative.