The U.S. Department of Energy is investigating the suitability of salt domes in the Mississippi salt-dome basin as repositories for storing radioactive wastes. The Department of Energy has requested that the U.S. Geological Survey describe the groundwater hydrology of the Mississippi salt-dome basin, giving special attention to direction and rate of movement of water. In this first part of a continuing investigation the data obtained from one year of extensive literature search and data compilation are summarized. The regional groundwater hydrology in the salt-dome basin is defined with respect to (1) groundwater flow, (2) facies changes, (3) geological structure, (4) recharge and discharge, (5) freshwater-saltwater relations, and (6) identification of localities where additional data are needed. From the 50 piercement-type salt domes in the Mississippi salt-dome basin three domes (Richton, Cypress Creek, and Lampton) were selected for more intensive study. To further evaluate the geohydrology of Richton, Lampton, and Cypress Creek domes as possible sites for storage of radioactive waste, an intensive geohydrologic study based on a comprehensive test drilling program near the domes is planned. (USGS)