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Effect of vitamin E on the immune response of channel catfish to Edwardsiella ictaluri

January 1, 1993

Three-month-old fingerling channel catfish Ictalurus punctatus were fed purified diets supplemented with ∝-tocopherol acetate to provide 0, 60, and 2,500 mg vitamin E/kg for 180 d. A 30-s immersion bath and an oral booster were used to deliver a bacterin of formalin-killed Edwardsiella ictaluri to half of the fish from each dietary treatment. Resistance of red blood cells to peroxidation was used as an index of antioxidant status. The susceptibility of red blood cells to oxidative hemolysis decreased with increasing levels of dietary vitamin E. Vaccinated and nonvaccinated fish were evaluated for agglutinating antibody titers and macrophage activity. Humoral antibody titers in response to E. ictaluri were significantly (P ≤ 0.05) higher in vaccinated fish than in nonvaccinated fish; however, no such differences in agglutinating antibody titers were detected among any of the dietary treatment groups. Both vaccination and vitamin E significantly enhanced the ability of macrophages to phagocytize virulent E. ictaluri. Results of this study indicate that elevated levels of dietary vitamin E may affect the ability of channel catfish to respond immunologically to bacterial pathogens.

Publication Year 1993
Title Effect of vitamin E on the immune response of channel catfish to Edwardsiella ictaluri
DOI 10.1577/1548-8667(1993)005<0183:EOVEOT>2.3.CO;2
Authors D.J. Wise, J.R. Tomasso, T.E. Schwedler, V. S. Blazer, D.M.I. Gatlin
Publication Type Article
Publication Subtype Journal Article
Series Title Journal of Aquatic Animal Health
Index ID 1014605
Record Source USGS Publications Warehouse
USGS Organization Leetown Science Center