Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine
The efficacy of a novel vaccine composed of three short recombinant subunit Pasteurella multocida toxin (PMT) proteins in combination with a bi-valent P. multocida whole-cell bacterin (rsPMT–PM) was evaluated in field studies for prevention and control of progressive atrophic rhinitis (PAR) of swine at 15 conventional farrow-to-finish farms. Experimental piglets that were immunized twice with the rsPMT–PM vaccine developed detectable titers of neutralizing antibodies (greater than 1:8) that prevented the growth retardation and pathological lesions typically observed following challenge with authentic PMT. A total of 542 sows were vaccinated once or twice prior to parturition and serum neutralizing antibody titers were evaluated. Both single and double vaccination protocols induced neutralizing antibody titers of 1:16 or higher in 62% and 74% of sows, respectively. Notably, neither sows nor piglets at a farm experiencing a severe outbreak of PAR at the time of the vaccination trial had detectable antibody titers, but antibody titers increased significantly to 1:16 or higher in 40% of sows following double vaccination. During the year after vaccination, clinical signs of PAR decreased in fattening pigs and growth performance improved sufficiently to reduce the rearing period until marketing by 2 weeks. Collectively, these results indicate that the rsPMT–PM vaccine could be used to provide protective immunity for controlling the prevalence and severity of PAR among farm-raised swine.
Citation Information
Publication Year | 2009 |
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Title | Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine |
DOI | 10.1016/j.vaccine.2009.03.005 |
Authors | Shih-Ling Hsuan, Chih-Ming Liao, Chienjin Huang, James R. Winton, Zeng-Weng Chen, Wei-Cheng Lee, Jiunn-Wang Liao, Ter-Hsin Chen, Chwei-Jang Chiou, Kuang-Sheng Yeh, Maw-Sheng Chien |
Publication Type | Article |
Publication Subtype | Journal Article |
Series Title | Vaccine |
Index ID | 70179323 |
Record Source | USGS Publications Warehouse |
USGS Organization | Western Fisheries Research Center |