In Fiscal Year 2006 (FY06), the U.S. Geological Survey (USGS) Fort Collins Science Center (FORT) continued research vital to U.S. Department of the Interior (DOI) science and management needs and associated USGS programmatic goals. FORT work also supported the science needs of other governmental departments and agencies as well as private cooperators. Specifically, FORT scientific research and technical assistance focused on client and partner agency needs and goals in the areas of biological information management, fisheries and aquatic systems, invasive species, status and trends of biological resources, terrestrial ecosystems, and wildlife resources. Highlights of FORT project accomplishments are described below under the USGS science program area with which each task is most closely associated.2 The work of FORT’s five branches (in 2006: Aquatic Systems and Technology Applications, Ecosystem Dynamics, Invasive Species Science, Policy Analysis and Science Assistance, and Species and Habitats of Federal Interest) often involves major partnerships with other agencies or cooperation with other USGS disciplines (Geology, Geography, Water Resources).