Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)
The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0·2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0·01, 0·05 and 0·2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0·01, 0·05 and 0·2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater adaptation of salmonids.
Citation Information
Publication Year | 1991 |
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Title | Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss) |
DOI | 10.1677/joe.0.1300087 |
Authors | S. D. McCormick, T. Sakamoto, S. Hasegawa, T. Hirano |
Publication Type | Article |
Publication Subtype | Journal Article |
Series Title | Journal of Endocrinology |
Index ID | 1014565 |
Record Source | USGS Publications Warehouse |
USGS Organization | Leetown Science Center |