The Northern Great Plains, an area of about 250,000 square miles in parts of Montana, North Dakota, South Dakota, and Wyoming, is underlain by an accumulation of sediments eroded from the Black Hills and from mountains to the west. Principal aquifers are areally extensive beds of sandstone within these sedimentary rocks, some at great depths. Anticipated future water needs dictate that available ground-water supplies be evaluated for management of this natural resource. The U.S. Geological Survey has started (1978) a 4-year study of the Northern Great Plains aquifer system. The objective of this study is to define availability and quality of ground water and to predict the effects of using this resource. To achieve this objective, the ground-water system will be described in terms of spatial distribution, hydraulics, geology, and geochemistry. Once described, the ground-water system will be simulated by mathematical models that will be used to define responses of the system to various management alternatives and assumed development patterns.