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Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

January 1, 2001

A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (Oncorhynchus mykiss) held at 15°C. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 μg.

Publication Year 2001
Title Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination
DOI 10.1016/S0264-410X(01)00113-X
Authors S. E. LaPatra, S. Corbeil, G. R. Jones, W. D. Shewmaker, N. Lorenzen, Eric Anderson, Gael Kurath
Publication Type Article
Publication Subtype Journal Article
Series Title Vaccine
Index ID 70023761
Record Source USGS Publications Warehouse
USGS Organization Western Fisheries Research Center