A survey of the helium concentration in soil-gas was conducted in the Red Desert Area, Sweetwater County, Wyoming. The area studied is directly over a low-grade uranium deposit that may be suitable for recovery by in-situ leaching techniques. The area was sampled twice, once in December, 1977, and again in July, 1978. Wind was a significant factor affecting the helium concentrations. Wind gusts exceeded 110 km/hr (70 mph) during the December, 1977, sampling; wind gusts did not exceed 30 km/hr (20 mph) during the July, 1978, sampling. The average helium concentration for all the July, 1978, soil-gas samples was about twice the average of the December, 1977, samples. In addition, a contour plot of the July, 1978, soil-gas samples showed an area of higher helium values that corresponds to the location of anomalies detected by other exploration techniques, and may be associated with the uranium deposit.