Six samples of group C eclogites from California and southwestern Oregon have initial Sr87/Sr86 ratios in the range of 0.7028 to 0.7051; Rb contents from less than 1 to 53.4 ppm; and Sr contents from 147 to 270 ppm. These data and major-element compositions suggest that the eclogites were derived from basalts older than but similar in composition to those intercalated with Mesozoic cugeosynclinal sedimentary rocks in California and western Oregon. The isotopic heterogeneity of the eclogites and associated graywackes contrasts with a uniformity of Sr87/Sr86 in many younger calc-alkaline volcanic rocks of the circum-Pacific province. Derivation of the younger volcanic rocks from an eclogite-blueschist melange isotopically similar to those investigated here would require isotopic homogenization or integrated partial melting over sufficient volumes so as to reduce these variations in the derived melts.