Two regional studies of big sagebrush (Artemisia tridentata), a widely distributed and dominant shrub in the western United States, have shown its responsiveness to known uranium mineralization in the Monument Hill and Pumpkin Buttes districts of the southern Powder River Basin, Wyoming, and the Uravan mineral belt area in southeastern Utah and southwestern Colorado. Uranium concentrations in the ash of 154 stem-and-leaf samples of sagebrush are plotted on two maps, one representing the sampling design for the Powder River Basin study, and the other representing the sampling design for the Colorado Plateaus, the Basin and Range, and the Columbia Plateaus physiographic provinces of the West. Sites having high concentrations in sagebrush correspond not only to the above uranium districts, but also reveal an area along the northeast flanks of the Owyhee Mountains in Idaho that should be further explored for its possible uranium potential.