A Landsat-derived vegetation map was prepared for Nowitna National Wildlife Refuge. The refuge lies within the middle boreal subzone of north central Alaska. Seven major vegetation classes and sixteen subclasses were recognized: forest (closed needleleaf, open needleleaf, needleleaf woodland, mixed, and broadleaf); broadleaf scrub (lowland, alluvial, subalpine); dwarf scrub (prostrate dwarf shrub tundra, dwarf shrub-graminoid tussock peatland); herbaceous (graminoid bog, marsh and meadow); scarcely vegetated areas (scarcely vegetated scree and floodplain); water (clear, turbid); and other areas (mountain shadow). The methodology employed a cluster-block technique. Sample areas were described based on a combination of helicopter-ground survey, aerial photointerpretation, and digital Landsat data. Major steps in the Landsat analysis involved preprocessing (geometric correction), derivation of statistical parameters for spectral classes, spectral class labeling of sample areas, preliminary classification of the entire study area using a maximum-likelihood algorithm, and final classification utilizing ancillary information such as digital elevation data. The final product is a 1:250,000-scale vegetation map representative of distinctive regional patterns and suitable for use in comprehensive conservation planning.