Carly Malavé (Former Employee)
Science and Products
Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2
We experimentally challenged wild Mexican free-tailed bats (TABR) with SARS-CoV-2 to determine the susceptibility, reservoir potential, and population impacts of infection in this species. Of nine bats oronasally inoculated with SARS-CoV-2, five became infected and orally excreted moderate amounts of virus for up to 18 days post inoculation. These five subjects all seroconverted and...
In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice
This work is part of an experimental trial to develop and assess novel recombinant raccoonpox virus (RCN) rabies vaccines in the mouse model, for potential use in bats. Briefly, our research group previously developed a recombinant RCN vaccine candidate expressing a mosaic glycoprotein (MoG) gene that protected mice and big brown bats when challenged with rabies virus (RABV). We...
Little brown bats (Myotis lucifugus) are resistant to SARS-CoV-2 infection Little brown bats (Myotis lucifugus) are resistant to SARS-CoV-2 infection
It has been proposed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that spread through human populations as a pandemic originated in Asian bats. There is concern that infected humans could transmit the virus to native North American bats; therefore, the susceptibility of several North American bat species to the pandemic virus has been experimentally...
Authors
Jeffrey S. Hall, Sean Nashold, Erik K. Hofmeister, Ariel Elizabeth Leon, Elizabeth Falendysz, Hon S. Ip, Carly M. Malave, Tonie E. Rocke, Mariano Carossino, Udeni B.R. Balasuriya, Susan Knowles
Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus is thought to have originated in wild bats from Asia, and as the resulting pandemic continues into its third year, concerns have been raised that the virus will expand its host range and infect North American wildlife species, including bats. Mexican free-tailed bats (Tadarida brasiliensis) live in large colonies in...
Authors
Jeffrey S. Hall, Erik K. Hofmeister, Hon S. Ip, Sean Nashold, Ariel Elizabeth Leon, Carly Marie Malave, Elizabeth Falendysz, Tonie E. Rocke, M. Carossino, U. Balasuriya, Susan Knowles
Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americas. Vaccination is being used to manage rabies in other wildlife reservoirs like fox and raccoon, but no rabies vaccine is available for...
Authors
Carly Marie Malave, Jaime Lopera-Madrid, Lex Guillermo Medina-Magues, Tonie E. Rocke, Jorge E. Osorio
Plague positive mouse fleas on mice prior to plague outbreaks in black-tailed and white-tailed prairie dogs Plague positive mouse fleas on mice prior to plague outbreaks in black-tailed and white-tailed prairie dogs
Plague is a lethal zoonotic disease associated with rodents worldwide. In the western United States, plague outbreaks can decimate prairie dog (Cynomys spp.) colonies. However, it is unclear where the causative agent, Yersinia pestis, of this flea-borne disease is maintained between outbreaks, and what triggers plague-induced prairie dog die-offs. Less susceptible rodent hosts, such as...
Authors
Gebbiena M. Bron, Carly Malave, Jesse T. Boulerice, Jorge E. Osorio, Tonie E. Rocke
Science and Products
Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2
We experimentally challenged wild Mexican free-tailed bats (TABR) with SARS-CoV-2 to determine the susceptibility, reservoir potential, and population impacts of infection in this species. Of nine bats oronasally inoculated with SARS-CoV-2, five became infected and orally excreted moderate amounts of virus for up to 18 days post inoculation. These five subjects all seroconverted and...
In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice
This work is part of an experimental trial to develop and assess novel recombinant raccoonpox virus (RCN) rabies vaccines in the mouse model, for potential use in bats. Briefly, our research group previously developed a recombinant RCN vaccine candidate expressing a mosaic glycoprotein (MoG) gene that protected mice and big brown bats when challenged with rabies virus (RABV). We...
Little brown bats (Myotis lucifugus) are resistant to SARS-CoV-2 infection Little brown bats (Myotis lucifugus) are resistant to SARS-CoV-2 infection
It has been proposed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that spread through human populations as a pandemic originated in Asian bats. There is concern that infected humans could transmit the virus to native North American bats; therefore, the susceptibility of several North American bat species to the pandemic virus has been experimentally...
Authors
Jeffrey S. Hall, Sean Nashold, Erik K. Hofmeister, Ariel Elizabeth Leon, Elizabeth Falendysz, Hon S. Ip, Carly M. Malave, Tonie E. Rocke, Mariano Carossino, Udeni B.R. Balasuriya, Susan Knowles
Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus is thought to have originated in wild bats from Asia, and as the resulting pandemic continues into its third year, concerns have been raised that the virus will expand its host range and infect North American wildlife species, including bats. Mexican free-tailed bats (Tadarida brasiliensis) live in large colonies in...
Authors
Jeffrey S. Hall, Erik K. Hofmeister, Hon S. Ip, Sean Nashold, Ariel Elizabeth Leon, Carly Marie Malave, Elizabeth Falendysz, Tonie E. Rocke, M. Carossino, U. Balasuriya, Susan Knowles
Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americas. Vaccination is being used to manage rabies in other wildlife reservoirs like fox and raccoon, but no rabies vaccine is available for...
Authors
Carly Marie Malave, Jaime Lopera-Madrid, Lex Guillermo Medina-Magues, Tonie E. Rocke, Jorge E. Osorio
Plague positive mouse fleas on mice prior to plague outbreaks in black-tailed and white-tailed prairie dogs Plague positive mouse fleas on mice prior to plague outbreaks in black-tailed and white-tailed prairie dogs
Plague is a lethal zoonotic disease associated with rodents worldwide. In the western United States, plague outbreaks can decimate prairie dog (Cynomys spp.) colonies. However, it is unclear where the causative agent, Yersinia pestis, of this flea-borne disease is maintained between outbreaks, and what triggers plague-induced prairie dog die-offs. Less susceptible rodent hosts, such as...
Authors
Gebbiena M. Bron, Carly Malave, Jesse T. Boulerice, Jorge E. Osorio, Tonie E. Rocke