Cathy Richter, PhD
Dr. Cathy Richter is a Research Molecular Biologist at the Columbia Environmental Research Center.
Science and Products
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Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development
Thiamin pyrophosphokinase (TPK) converts thiamin to its active form, thiamin diphosphate. In humans, TPK expression is down-regulated in some thiamin deficiency related syndrome, and enhanced during pregnancy. Rainbow trout are also vulnerable to thiamin deficiency in wild life and are useful models for thiamin metabolism research. We identified the tpk gene transcript including seven...
Authors
Shinya Yuge, Catherine A. Richter, Maureen K. Wright-Osment, Diane Nicks, Stephanie K. Saloka, Donald E. Tillitt, Weiming Li
Paenibacillus thiaminolyticus is not the cause of thiamine deficiency impeding lake trout (Salvelinus namaycush) recruitment in the Great Lakes
Thiamine (vitamin B1) deficiency is a global concern affecting wildlife, livestock, and humans. In Great Lakes salmonines, thiamine deficiency causes embryo mortality and is an impediment to restoration of native lake trout (Salvelinus namaycush) stocks. Thiamine deficiency in fish may result from a diet of prey with high levels of thiaminase I. The discoveries that the bacterial species...
Authors
Catherine A. Richter, Allison N. Evans, Maureen K. Wright-Osment, James L. Zajicek, Scott A. Heppell, Stephen Riley, Charles C. Krueger, Donald E. Tillitt
Gene expression changes in female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury
Methylmercury (MeHg) is a potent neurotoxicant and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. The gene expression profile in adult female zebrafish whole brain induced by acute (96 h) MeHg exposure was investigated. Fish were...
Authors
Catherine A. Richter, Natalia Garcia-Reyero, Christopher J. Martyniuk, Iris Knoebl, Marie Pope, Maureen K. Wright-Osment, Nancy P. Denslow, Donald E. Tillitt
Atrazine reduces reproduction in fathead minnow (Pimephales promelas)
Atrazine, the widely used herbicide, has shown to affect the hypothalamus–pituitary–gonad axis in certain vertebrate species, but few studies have examined reproductive effects of this chemical on fish. Our study was designed to evaluate a population endpoint (egg production) in conjunction with histological (e.g., gonad development) and biochemical (e.g., hormone production) phenotypes...
Authors
Donald E. Tillitt, Diana M. Papoulias, Jeffrey J. Whyte, Catherine A. Richter
Dreissenid mussels from the Great Lakes contain elevated thiaminase activity
We examined thiaminase activity in dreissenid mussels collected at different depths and seasons, and from various locations in Lakes Michigan, Ontario, and Huron. Here we present evidence that two dreissenid mussel species (Dreissena bugensis and D. polymorpha) contain thiaminase activity that is 5-100 fold greater than observed in Great Lakes fishes. Thiaminase activity in zebra mussels...
Authors
Donald E. Tillitt, S.C. Riley, A.N. Evans, S. Jerrine Nichols, J.L. Zajicek, J. Rinchard, C.A. Richter, C.C. Krueger
Quantitative polymerase chain reaction (PCR) assays for a bacterial thiaminase I gene and the thiaminase-producing bacterium Paenibacillus thiaminolyticus.
The thiaminase I enzyme produced by the gram-positive bacterium Paenibacillus thiaminolyticus isolated from the viscera of Lake Michigan alewives Alosa pseudoharengus is currently the only defined source of the thiaminase activity linked to thiamine (vitamin B1) deficiency in early mortality syndrome (EMS) in the larvae of Great Lakes salmonines. Diets of alewife or isolated strains of P...
Authors
C.A. Richter, Maureen K. Wright-Osment, J.L. Zajicek, Dale C. Honeyfield, Donald E. Tillitt
The genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute exposure to the androgen, 17β-trenbolone
We investigated the genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute (4 days) exposure to 0.1 or 1.0 ??g/L of 17??-trenbolone (TB), the active metabolite of an anabolic androgenic steroid used as a growth promoter in cattle and a contaminant of concern in aquatic systems. Our objectives were to investigate the gene expression profile induced by...
Authors
Jennifer Dorts, Catherine A. Richter, Maureen K. Wright-Osment, Mark R. Ellersieck, Barbara J. Carter, Donald E. Tillitt
Use of a 15 k gene microarray to determine gene expression changes in response to acute and chronic methylmercury exposure in the fathead minnow Pimephales promelas Rafinesque
This study describes the use of a 15 000 gene microarray developed for the toxicological model species, Pimephales promelas, in investigating the impact of acute and chronic methylmercury exposures in male gonad and liver tissues. The results show significant differences in the individual genes that were differentially expressed in response to each treatment. In liver, a total of 650...
Authors
R. D. Klaper, Barbara J. Carter, C.A. Richter, Paul E. Drevnick, Mark B. Sandheinrich, Donald E. Tillitt
Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
This document is a summary statement of the outcome from the meeting: “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health” sponsored by both the NIEHS and NIDCR at NIH/DHHS, as well as the US-EPA and Commonweal on the estrogenic environmental chemical bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl)propane; CAS...
Authors
Frederick S. vom Saal, Benson T. Akingbemi, Scott M. Belcher, Linda S. Birnbaum, D. Andrew Crain, Marcus Eriksen, Francesca Farabollini, Louis J. Guillette, Russ Hauser, Jerrold J. Heindel, Shuk-Mei Ho, Patricia A. Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Ruth A. Keri, Karen E. Knudsen, Hans Laufer, Gerald A. LeBlanc, Michele Marcus, John A. McLachlan, John Peterson Myers, Angel Nadal, Retha R. Newbold, Nicolas Olea, Gail S. Prins, Catherine A. Richter, Beverly S. Rubin, Carlos Sonnenschein, Ana M. Soto, Chris E. Talsness, John G. Vandenbergh, Laura N. Vanderberg, Debby R. Walser-Kuntz, Cheryl S. Watson, Wade V. Welshons, Yelena Wetherill, R. Thomas Zoeller
In vivo effects of bisphenol A in laboratory rodent studies
Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/(kg day), in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the...
Authors
Catherine A. Richter, Linda S. Birnbaum, Francesca Farabollini, Retha R. Newbold, Beverly S. Rubin, Chris E. Talsness, John G. Vandenbergh, Debby R. Walser-Kuntz, Frederick S. vom Saal
Regulation of subcellular localization of the Aryl Hydrocarbon Receptor (AhR)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and other xenobiotics. In the absence of exogenous ligand, AhR is cytosolic. We investigated how AhR is retained in the cytosol and how dioxin induces AhR to move to the nucleus. Disruption of nuclear export of AhR by the nuclear export inhibitor leptomycin B (LMB) or by...
Authors
Catherine A. Richter, Donald E. Tillitt, Mark Hannink
Non-USGS Publications**
Taylor, J.A., Richter, C.A., Suzuki, A., Watanabe, H., Iguchi, T., Coser, K.R., Shioda, T., and vom Saal, F.S., 2012, Dose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells: PLOS ONE, v. 7, no. 10, p. e48311
Taylor, J.A., Richter, C.A., Ruhlen, R.L., and vom Saal, F.S., 2011, Estrogenic environmental chemicals and drugs: Mechanisms for effects on the developing male urogenital system: The Journal of Steroid Biochemistry and Molecular Biology, v. 127, no. 1, p. 83-95
Richter, C.A., Taylor, J.A., Ruhlen, R.L., Welshons, W.V., and vom Saal, F.S., 2007, Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells: Environmental Health Perspectives, v. 115, no. 6, p. 902-908
vom Saal, F.S., Richter, C.A., Mao, J., and Welshons, W.V., 2005, Commercial animal feed: Variability in estrogenic activity and effects on body weight in mice: Birth Defects Research Part A: Clinical and Molecular Teratology, v. 73, no. 7, p. 474-475
Timms, B.G., Howdeshell, K.L., Barton, L., Bradley, S., Richter, C.A., and vom Saal, F.S., 2005, Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra: Proceedings of the National Academy of Sciences of the United States of America, v. 102, no. 19, p. 7014-7019
Richter, C., Timms, B., and vom Saal, F., 2005, Prostate development: mechanisms for opposite effects of low and high doses of estrogenic chemicals, in Naz, R., ed., Endocrine Disruptors: Effects on Male and Female Reproductive Systems: New York, CRC Press, p. 379-410.
vom Saal, F.S., Richter, C.A., Ruhlen, R.R., Nagel, S.C., Timms, B.G., and Welshons, W.V., 2005, The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A: Birth Defects Research Part A: Clinical and Molecular Teratology, v. 73, no. 3, p. 140-145
vom Saal, F.S., Richter, C.A., Ruhlen, R.R., Nagel, S.C., and Welshons, W.V., 2004, Disruption of laboratory experiments due to leaching of Bisphenol A from polycarbonate cages and bottles and uncontrolled variability in components of animal feed, in National Research Council, ed., The Development of Science-based Guidelines for Laboratory Animal Care: Proceedings of the November 2003 International Workshop: The National Academies Press, p. 65-69.
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
Science and Products
Filter Total Items: 20
No Result Found
Filter Total Items: 47
Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development
Thiamin pyrophosphokinase (TPK) converts thiamin to its active form, thiamin diphosphate. In humans, TPK expression is down-regulated in some thiamin deficiency related syndrome, and enhanced during pregnancy. Rainbow trout are also vulnerable to thiamin deficiency in wild life and are useful models for thiamin metabolism research. We identified the tpk gene transcript including seven...
Authors
Shinya Yuge, Catherine A. Richter, Maureen K. Wright-Osment, Diane Nicks, Stephanie K. Saloka, Donald E. Tillitt, Weiming Li
Paenibacillus thiaminolyticus is not the cause of thiamine deficiency impeding lake trout (Salvelinus namaycush) recruitment in the Great Lakes
Thiamine (vitamin B1) deficiency is a global concern affecting wildlife, livestock, and humans. In Great Lakes salmonines, thiamine deficiency causes embryo mortality and is an impediment to restoration of native lake trout (Salvelinus namaycush) stocks. Thiamine deficiency in fish may result from a diet of prey with high levels of thiaminase I. The discoveries that the bacterial species...
Authors
Catherine A. Richter, Allison N. Evans, Maureen K. Wright-Osment, James L. Zajicek, Scott A. Heppell, Stephen Riley, Charles C. Krueger, Donald E. Tillitt
Gene expression changes in female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury
Methylmercury (MeHg) is a potent neurotoxicant and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. The gene expression profile in adult female zebrafish whole brain induced by acute (96 h) MeHg exposure was investigated. Fish were...
Authors
Catherine A. Richter, Natalia Garcia-Reyero, Christopher J. Martyniuk, Iris Knoebl, Marie Pope, Maureen K. Wright-Osment, Nancy P. Denslow, Donald E. Tillitt
Atrazine reduces reproduction in fathead minnow (Pimephales promelas)
Atrazine, the widely used herbicide, has shown to affect the hypothalamus–pituitary–gonad axis in certain vertebrate species, but few studies have examined reproductive effects of this chemical on fish. Our study was designed to evaluate a population endpoint (egg production) in conjunction with histological (e.g., gonad development) and biochemical (e.g., hormone production) phenotypes...
Authors
Donald E. Tillitt, Diana M. Papoulias, Jeffrey J. Whyte, Catherine A. Richter
Dreissenid mussels from the Great Lakes contain elevated thiaminase activity
We examined thiaminase activity in dreissenid mussels collected at different depths and seasons, and from various locations in Lakes Michigan, Ontario, and Huron. Here we present evidence that two dreissenid mussel species (Dreissena bugensis and D. polymorpha) contain thiaminase activity that is 5-100 fold greater than observed in Great Lakes fishes. Thiaminase activity in zebra mussels...
Authors
Donald E. Tillitt, S.C. Riley, A.N. Evans, S. Jerrine Nichols, J.L. Zajicek, J. Rinchard, C.A. Richter, C.C. Krueger
Quantitative polymerase chain reaction (PCR) assays for a bacterial thiaminase I gene and the thiaminase-producing bacterium Paenibacillus thiaminolyticus.
The thiaminase I enzyme produced by the gram-positive bacterium Paenibacillus thiaminolyticus isolated from the viscera of Lake Michigan alewives Alosa pseudoharengus is currently the only defined source of the thiaminase activity linked to thiamine (vitamin B1) deficiency in early mortality syndrome (EMS) in the larvae of Great Lakes salmonines. Diets of alewife or isolated strains of P...
Authors
C.A. Richter, Maureen K. Wright-Osment, J.L. Zajicek, Dale C. Honeyfield, Donald E. Tillitt
The genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute exposure to the androgen, 17β-trenbolone
We investigated the genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute (4 days) exposure to 0.1 or 1.0 ??g/L of 17??-trenbolone (TB), the active metabolite of an anabolic androgenic steroid used as a growth promoter in cattle and a contaminant of concern in aquatic systems. Our objectives were to investigate the gene expression profile induced by...
Authors
Jennifer Dorts, Catherine A. Richter, Maureen K. Wright-Osment, Mark R. Ellersieck, Barbara J. Carter, Donald E. Tillitt
Use of a 15 k gene microarray to determine gene expression changes in response to acute and chronic methylmercury exposure in the fathead minnow Pimephales promelas Rafinesque
This study describes the use of a 15 000 gene microarray developed for the toxicological model species, Pimephales promelas, in investigating the impact of acute and chronic methylmercury exposures in male gonad and liver tissues. The results show significant differences in the individual genes that were differentially expressed in response to each treatment. In liver, a total of 650...
Authors
R. D. Klaper, Barbara J. Carter, C.A. Richter, Paul E. Drevnick, Mark B. Sandheinrich, Donald E. Tillitt
Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
This document is a summary statement of the outcome from the meeting: “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health” sponsored by both the NIEHS and NIDCR at NIH/DHHS, as well as the US-EPA and Commonweal on the estrogenic environmental chemical bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl)propane; CAS...
Authors
Frederick S. vom Saal, Benson T. Akingbemi, Scott M. Belcher, Linda S. Birnbaum, D. Andrew Crain, Marcus Eriksen, Francesca Farabollini, Louis J. Guillette, Russ Hauser, Jerrold J. Heindel, Shuk-Mei Ho, Patricia A. Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Ruth A. Keri, Karen E. Knudsen, Hans Laufer, Gerald A. LeBlanc, Michele Marcus, John A. McLachlan, John Peterson Myers, Angel Nadal, Retha R. Newbold, Nicolas Olea, Gail S. Prins, Catherine A. Richter, Beverly S. Rubin, Carlos Sonnenschein, Ana M. Soto, Chris E. Talsness, John G. Vandenbergh, Laura N. Vanderberg, Debby R. Walser-Kuntz, Cheryl S. Watson, Wade V. Welshons, Yelena Wetherill, R. Thomas Zoeller
In vivo effects of bisphenol A in laboratory rodent studies
Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/(kg day), in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the...
Authors
Catherine A. Richter, Linda S. Birnbaum, Francesca Farabollini, Retha R. Newbold, Beverly S. Rubin, Chris E. Talsness, John G. Vandenbergh, Debby R. Walser-Kuntz, Frederick S. vom Saal
Regulation of subcellular localization of the Aryl Hydrocarbon Receptor (AhR)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and other xenobiotics. In the absence of exogenous ligand, AhR is cytosolic. We investigated how AhR is retained in the cytosol and how dioxin induces AhR to move to the nucleus. Disruption of nuclear export of AhR by the nuclear export inhibitor leptomycin B (LMB) or by...
Authors
Catherine A. Richter, Donald E. Tillitt, Mark Hannink
Non-USGS Publications**
Taylor, J.A., Richter, C.A., Suzuki, A., Watanabe, H., Iguchi, T., Coser, K.R., Shioda, T., and vom Saal, F.S., 2012, Dose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells: PLOS ONE, v. 7, no. 10, p. e48311
Taylor, J.A., Richter, C.A., Ruhlen, R.L., and vom Saal, F.S., 2011, Estrogenic environmental chemicals and drugs: Mechanisms for effects on the developing male urogenital system: The Journal of Steroid Biochemistry and Molecular Biology, v. 127, no. 1, p. 83-95
Richter, C.A., Taylor, J.A., Ruhlen, R.L., Welshons, W.V., and vom Saal, F.S., 2007, Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells: Environmental Health Perspectives, v. 115, no. 6, p. 902-908
vom Saal, F.S., Richter, C.A., Mao, J., and Welshons, W.V., 2005, Commercial animal feed: Variability in estrogenic activity and effects on body weight in mice: Birth Defects Research Part A: Clinical and Molecular Teratology, v. 73, no. 7, p. 474-475
Timms, B.G., Howdeshell, K.L., Barton, L., Bradley, S., Richter, C.A., and vom Saal, F.S., 2005, Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra: Proceedings of the National Academy of Sciences of the United States of America, v. 102, no. 19, p. 7014-7019
Richter, C., Timms, B., and vom Saal, F., 2005, Prostate development: mechanisms for opposite effects of low and high doses of estrogenic chemicals, in Naz, R., ed., Endocrine Disruptors: Effects on Male and Female Reproductive Systems: New York, CRC Press, p. 379-410.
vom Saal, F.S., Richter, C.A., Ruhlen, R.R., Nagel, S.C., Timms, B.G., and Welshons, W.V., 2005, The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A: Birth Defects Research Part A: Clinical and Molecular Teratology, v. 73, no. 3, p. 140-145
vom Saal, F.S., Richter, C.A., Ruhlen, R.R., Nagel, S.C., and Welshons, W.V., 2004, Disruption of laboratory experiments due to leaching of Bisphenol A from polycarbonate cages and bottles and uncontrolled variability in components of animal feed, in National Research Council, ed., The Development of Science-based Guidelines for Laboratory Animal Care: Proceedings of the November 2003 International Workshop: The National Academies Press, p. 65-69.
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.