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Find out more about Biological Threat and Invasive Species Research through our publications.

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Chronic wasting disease—Status, science, and management support by the U.S. Geological Survey

The U.S. Geological Survey (USGS) investigates chronic wasting disease (CWD) at multiple science centers and cooperative research units across the Nation and supports the management of CWD through science-based strategies. CWD research conducted by USGS scientists has three strategies: (1) to understand the biology, ecology, and causes and distribution of CWD; (2) to assess and predict the spread
Authors
Christina M. Carlson, M. Camille Hopkins, Natalie T. Nguyen, Bryan J. Richards, Daniel P. Walsh, W. David Walter

High‐prevalence and low‐intensity Ichthyophonus infections in Pacific Halibut

Ichthyophonus occurred at high prevalence but low intensity in Pacific Halibut Hippoglossus stenolepis throughout the West Coast of North America, ranging from coastal Oregon to the Bering Sea. Infection prevalence in adults was variable on spatial and temporal scales, with the lowest prevalence typically occurring on the edges of the geographic range and highest prevalence consistently occurring
Authors
Paul Hershberger, Jacob L. Gregg, Claude L. Dykstra

Imperfect pathogen detection from non-invasive skin swabs biases disease inference

1. Conservation managers rely on accurate estimates of disease parameters, such as pathogen prevalence and infection intensity, to assess disease status of a host population. However, these disease metrics may be biased if low-level infection intensities are missed by sampling methods or laboratory diagnostic tests. These false negatives underestimate pathogen prevalence and overestimate mean infe
Authors
Graziella V. DiRenzo, Evan H. Campbell Grant, Ana V. Longo, Christian Che-Castaldo, Kelly R. Zamudio, Karen Lips

Virulence of a chimeric recombinant infectious haematopoietic necrosis virus expressing the spring viraemia of carp virus glycoprotein in salmonid and cyprinid fish

Infectious haematopoietic necrosis virus (IHNV) and spring viraemia of carp virus (SVCV) are both rhabdoviruses of fish, listed as notifiable disease agents by the World Organization for Animal Health. Recombinant rhabdoviruses with heterologous gene substitutions have been engineered to study genetic determinants and assess the potential of these recombinant viruses for vaccine development. A rec
Authors
Eveline Emmenegger, Stéphane Biacchesi, Emilie Mérour, Jolene. A Glenn, Alexander D. Palmer, Michel Brémont, Gael Kurath

Molecular testing of adult Pacific salmon and trout (Oncorhynchus spp.) for several RNA viruses demonstrates widespread distribution of piscine orthoreovirus in Alaska and Washington

This research was initiated in conjunction with a systematic, multiagency surveillance effort in the United States (U.S.) in response to reported findings of infectious salmon anaemia virus (ISAV) RNA in British Columbia, Canada. In the systematic surveillance study reported in a companion paper, tissues from various salmonids taken from Washington and Alaska were surveyed for ISAV RNA using the U
Authors
Maureen K. Purcell, Rachel L. Thompson, Joy Evered, John Kerwin, Ted R. Meyers, Bruce Stewart, James Winton

Patterns of circulating corticosterone in a population of rattlesnakes afflicted with snake fungal disease: Stress hormones as a potential mediator of seasonal cycles in disease severity and outcomes

Snake fungal disease (SFD) is an emerging threat to snake populations in the United States. Fungal pathogens are often associated with a physiological stress response mediated by the hypothalamo-pituitary-adrenal axis (HPA), and afflicted individuals may incur steep coping costs. The severity of SFD can vary seasonally; however, little is known regarding (1) how SFD infection relates to HPA activi
Authors
Craig M. Lind, Ignacio T. Moore, Çağlar Akçay, Ben J. Vernasco, Jeffrey M. Lorch, Terence M. Farrell

Snake fungal disease in North America: U.S. Geological Survey updates

Snake fungal disease (SFD) results from a skin infection that has been documented only in snakes. Historically, reports of snakes with skin infections of unknown origin have been sporadic. Recently, the number of reported cases of skin infections in snakes has increased substantially. This emerging infectious disease, confirmed in numerous species of snakes, is caused by the fungus Ophidiomyces op
Authors
Noelle E. Thompson, Emily W. Lankau, Gail Moede Rogall

Batrachochytrium salamandriovrans (Bsal) in Appalachia—Using scenario building to proactively prepare for a wildlife disease outbreak caused by an invasive amphibian chytrid fungus

Batrachochytrium salamandrivorans (Bsal), a pathogenic chytrid fungus, is nonnative to the United States and poses a disease threat to vulnerable amphibian hosts. The Bsal fungus may lead to increases in threatened, endangered, and sensitive status listings at State, Tribal, and Federal levels, resulting in financial costs associated with implementing the Endangered Species Act of 1973. The United
Authors
M. Camille Hopkins, M. J. Adams, P.E. Super, D.H. Olson, C.R. Hickman, P. English, L. Sprague, I.B. Maska, A.B. Pennaz, K. A. Ludwig

Serologic surveillance of wild and pen-reared ring-necked pheasants (Phasianus colchicus) as a method of understanding disease reservoirs

We investigated exposure to infectious diseases in wild (n=33) and pen-reared (n=12) Ring-necked Pheasants (Phasianus colchicus) in the Central Valley of California during 2014 and 2015. Serologic tests were positive for antibodies against hemorrhagic enteritis (HE), infectious bursal disease (IBD), and Newcastle disease (ND) viruses in both wild and pen-reared pheasants.
Authors
Ian Dwight, Peter S. Coates, Simone T. Stoute, C. Gabriel Senties-Cue, Radhika V. Gharpure, Maurice E. Pitesky

First evidence of bighead carp wild recruitment in Western Europe, and its relation to hydrology and temperature

Bighead carp (Hypophthalmichthys nobilis) have been introduced throughout Europe, mostly unintentionally, and little attention has been given to their potential for natural reproduction. We investigated the presence of young-of-the-year bighead carp in an irrigation canal network of Northern Italy and the environmental conditions associated with spawning in 2011–2015. The adult bighead carp popula
Authors
Marco Milardi, Duane Chapman, James M. Long, Giuseppe Castaldelli

Fear of feces? Trade-offs between disease risk and foraging drive animal activity around raccoon latrines

Fear of predation alters prey behavior, which can indirectly alter entire landscapes. A parasite-induced ecology of fear might also exist if animals avoid parasite-contaminated resources when infection costs outweigh foraging benefits. To investigate whether animals avoid parasite contaminated sites, and if such avoidance balances disease costs and foraging gains, we monitored animal behavior at r
Authors
Sara B. Weinstein, Chad W. Moura, Jon Francis Mendez, Kevin D. Lafferty

MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans

We examined the associations between California sea lion MHC class II DRB (Zaca-DRB) configuration and diversity, and leptospirosis. As Zaca-DRB gene sequences are involved with antigen presentation of bacteria and other extracellular pathogens, we predicted that they would play a role in determining responses to these pathogenic spirochaetes. Specifically, we investigated whether Zaca-DRB diversi
Authors
Karina Acevedo-Whitehouse, Frances Gulland, Lizabeth Bowen
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