Bioassays

About the Research The Organic Geochemistry Research Laboratory Core Technology Team (CTT) as part of the Environmental Health Program works to develop targeted and non-targeted analytical methods for the identification and quantitation of chemicals that can impact the health of humans and other organisms, and uses bioassays to screen for receptor inhibition.

About the Research The Functional and Molecular Bioassay Core Technology Team (CTT) as part of the Environmental Health Program utilizes reporter assays, quantitative gene expression analyses, and high-throughput sequencing methods to produce functional endpoints across a broad scope of environmental topics and sample matrices.

The team studies toxicants and pathogens in water resources from their sources, through watersheds, aquifers, and infrastructure to human and wildlife exposures. That information is used to develop decision tools that protect human and wildlife health.

The team develops advanced methods to study factors driving algal toxin production, how and where wildlife or humans are exposed to toxins, and ecotoxicology. That information is used to develop decision tools to understand if ​ toxin exposure leads to adverse health effects in order to protect human and wildlife health.

The Immunomodulation Integrated Science Team focuses on contaminant and pathogen exposures in the environment that might influence the immune systems of wildlife and the connection to their shared environment with humans. In collaboration with public-health officials, the Team also addresses potential human-health risks stemming from similar exposures. If actual risks are identified, this Team...

To understand if contaminants are associated with white sturgeon population declines, U.S. Geological Survey scientists reviewed the life history, physiology, and behavior of white sturgeon, along with recent toxicological studies and existing trace metal data for locations in the Columbia River. The analysis indicated that the highest concentrations of copper and other metals in the Columbia...

The Energy Lifecycle Integrated Science Team focuses on the potential for contaminant exposures in the environment that might originate from energy resource activities including, extraction, production, transportation, storage, extraction, waste management and restoration. Perceived health risks to humans and other organisms will be distinguished from actual risks, if any. If actual risks are...

Cyanobacterial bloom magnitude during 2003–11 was quantified and ranked in Florida and Ohio lakes with a newly developed modelling tool that allows for the use of multiple satellite data sources and user-defined thresholds. This tool was designed to identify the magnitude of algal blooms, but one metric alone cannot adequately represent the severity of a bloom of interest in terms of toxicity. The...

Refinement of the existing national-scale “de facto reuse incidence in our nation’s consumable supply” (DRINCS) model, complemented by field measurements, provides a screening tool to understand human and wildlife exposure to toxicants and pathogens associated with the incidental reuse of treated wastewater in the Shenandoah River watershed. The model results can be accessed in a companion web...

Raised black lesions observed in 30 percent of the brown bullhead collected from two sites in Lake Memphremagog from 2014 through 2017 were identified microscopically as malignant melanoma. Malignant melanoma in freshwater fishes has been reported before, but this cancer occurrence cluster is raising questions about the cause of the tumors and the implications for the long-term health of fish...

Science from the U.S. Geological Survey (USGS) and other entities has shown that a mixture of natural and synthetic estrogens and other similar chemicals are discharged from wastewater treatment plants (WWTPs) to streams and rivers.

The team studies the movement of toxicants and pathogens that could originate from the growing, raising, and processing/manufacturing of plant and animal products through the environment where exposure can occur. This information is used to understand if there are adverse effects upon exposure and to develop decision tools to protect health.