Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
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Resistance to plague among black-tailed prairie dog populations
In some rodent species frequently exposed to plague outbreaks caused by Yersinia pestis, resistance to the disease has evolved as a population trait. As a first step in determining if plague resistance has developed in black-tailed prairie dogs (Cynomys ludovicianus), animals captured from colonies in a plague-free region (South Dakota) and two plague-endemic regions (Colorado and Texas) were chal
Authors
Tonie E. Rocke, Judy Williamson, Kacy R. Cobble, Joseph D. Busch, Michael F. Antolin, David M. Wagner
Sylvatic plague vaccine: combating plague in prairie dogs and black-footed ferrets
After achieving promising results in laboratory trials, researchers at the USGS National Wildlife Health Center (NWHC) and University of Wisconsin at Madison will soon begin field testing a new oral vaccine for sylvatic plague, a devastating disease affecting prairie dogs and other mammals, particularly the endangered black-footed ferret. Our team has developed and is currently registering a sylva
Authors
Tonie E. Rocke, Rachel C. Abbott
Resistance to plague among black-tailed prairie dog populations
In some rodent species frequently exposed to plague outbreaks caused by Yersinia pestis, resistance to the disease has evolved as a population trait. As a first step in determining if plague resistance has developed in black-tailed prairie dogs (Cynomys ludovicianus), animals captured from colonies in a plague-free region (South Dakota) and two plague-endemic regions (Colorado and Texas) were chal
Assessment of a recombinant F1-V fusion protein vaccine intended to protect Canada lynx (Lynx canadensis) from plague
As part of an ongoing restoration program in Colorado, USA, we evaluated adverse reactions and seroconversion in captive Canada lynx (Lynx canadensis) after vaccination with a recombinant F1-V fusion protein vaccine against Yersinia pestis, the bacterium that causes plague. Ten adult female lynx received the F1-V vaccine; 10 source- and age-matched lynx remained unvaccinated as controls. All of th
Authors
Lisa L. Wolfe, Tanya M. Shenk, Bradford Powell, Tonie E. Rocke
Population differences in host immune factors may influence survival of Gunnison's prairie dogs (Cynomys Gunnisoni) during plague outbreaks
Over the past 40 yr, epizootics of plague (Yersinia pestis) in northern Arizona have reduced populations of the Gunnison’s prairie dog (Cynomys gunnisoni), with the exception of a large population found in the Aubrey Valley (AV). To examine potential mechanisms accounting for their survival, we collected prairie dog serum samples in 2005–2006 from AV and a neighboring population near Seligman (SE)
Authors
Joseph D. Busch, Roger Van Andel, Jennifer Cordova, Rebecca E. Colman, Paul Keim, Tonie E. Rocke, Jeff G. Leid, William E. Van Pelt, David M. Wagner
Antigenic profiling of Yersinia pestis infection in the Wyoming coyote (Canis latrans)
Although Yersinia pestis is classified as a "high-virulence" pathogen, some host species are variably susceptible to disease. Coyotes (Canis latrans) exhibit mild, if any, symptoms during infection, but antibody production occurs postinfection. This immune response has been reported to be against the F1 capsule, although little subsequent characterization has been conducted. To further define the
Authors
G. Vernati, W.H. Edwards, T.E. Rocke, S.F. Little, G.P. Andrews
Degradation of the disease-associated prion protein by a serine protease from lichens
The disease-associated prion protein (PrP(TSE)), the probable etiological agent of the transmissible spongiform encephalopathies (TSEs), is resistant to degradation and can persist in the environment. Lichens, mutualistic symbioses containing fungi, algae, bacteria and occasionally cyanobacteria, are ubiquitous in the environment and have evolved unique biological activities allowing their surviva
Authors
C.J. Johnson, J. P. Bennett, S.M. Biro, J.C. Duque-Velasquez, C.M. Rodriguez, R. A. Bessen, T.E. Rocke
Degradation of the disease-associated prion protein by a serine protease from lichens.
The disease-associated prion protein (PrPTSE), the probable etiological agent of the transmissible spongiform encephalopathies (TSEs), is resistant to degradation and can persist in the environment. Lichens, mutualistic symbioses containing fungi, algae, bacteria and occasionally cyanobacteria, are ubiquitous in the environment and have evolved unique biological activities allowing their survival
Authors
Christopher J. Johnson, James P. Bennett, S.M. Biro, J. C. Duque-Velasquez, Cynthia M. Rodriguez, R. A. Bessen, Tonie E. Rocke
Population differences in host immune factors may influence survival of Gunnison's prairie dogs (Cynomys gunnisoni) during plague outbreaks
Over the past 40 yr, epizootics of plague (Yersinia pestis) in northern Arizona have reduced populations of the Gunnison's prairie dog (Cynomys gunnisoni), with the exception of a large population found in the Aubrey Valley (AV). To examine potential mechanisms accounting for their survival, we collected prairie dog serum samples in 2005-2006 from AV and a neighboring population near Seligman (SE)
Authors
J.D. Busch, Andel R. van, J. Cordova, Rebecca E. Colman, P. Keim, Tonie E. Rocke, Jeff G. Leid, W.E. van Pelt, D.M. Wagner
Use of Rhodamine B as a biomarker for oral plague vaccination of prairie dogs
Oral vaccination against Yersinia pestis could provide a feasible approach for controlling plague in prairie dogs (Cynomys spp.) for conservation and public health purposes. Biomarkers are useful in wildlife vaccination programs to demonstrate exposure to vaccine baits. Rhodamine B (RB) was tested as a potential biomarker for oral plague vaccination because it allows nonlethal sampling of animals
Authors
Julia Rodriguez-Ramos Fernandez, Tonie E. Rocke
Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus)
Baits containing recombinant raccoon poxvirus (RCN) expressing plague antigens (fraction 1 [F1] and a truncated form of the V protein-V307) were offered for voluntary consumption several times over the course of several months to a group of 16 black-tailed prairie dogs (Cynomys ludovicianus). For comparison, another group of prairie dogs (n = 12) was injected subcutaneously (SC) (prime and boost)
Authors
Tonie E. Rocke, Nicola Pussini, Susan Smith, Judy L. Williamson, Bradford Powell, Jorge E. Osorio
Enzootic plague reduces black-footed ferret (Mustela nigripes) survival in Montana
Black-footed ferrets (Mustela nigripes) require extensive prairie dog colonies (Cynomys spp.) to provide habitat and prey. Epizootic plague kills both prairie dogs and ferrets and is a major factor limiting recovery of the highly endangered ferret. In addition to epizootics, we hypothesized that enzootic plague, that is, presence of disease-causing Yersinia pestis without any noticeable prairie do
Authors
Marc R. Matchett, Dean E. Biggins, Valerie Carlson, Bradford Powell, Tonie E. Rocke
Science and Products
Filter Total Items: 14
No Result Found
Filter Total Items: 133
Resistance to plague among black-tailed prairie dog populations
In some rodent species frequently exposed to plague outbreaks caused by Yersinia pestis, resistance to the disease has evolved as a population trait. As a first step in determining if plague resistance has developed in black-tailed prairie dogs (Cynomys ludovicianus), animals captured from colonies in a plague-free region (South Dakota) and two plague-endemic regions (Colorado and Texas) were chal
Authors
Tonie E. Rocke, Judy Williamson, Kacy R. Cobble, Joseph D. Busch, Michael F. Antolin, David M. Wagner
Sylvatic plague vaccine: combating plague in prairie dogs and black-footed ferrets
After achieving promising results in laboratory trials, researchers at the USGS National Wildlife Health Center (NWHC) and University of Wisconsin at Madison will soon begin field testing a new oral vaccine for sylvatic plague, a devastating disease affecting prairie dogs and other mammals, particularly the endangered black-footed ferret. Our team has developed and is currently registering a sylva
Authors
Tonie E. Rocke, Rachel C. Abbott
Resistance to plague among black-tailed prairie dog populations
In some rodent species frequently exposed to plague outbreaks caused by Yersinia pestis, resistance to the disease has evolved as a population trait. As a first step in determining if plague resistance has developed in black-tailed prairie dogs (Cynomys ludovicianus), animals captured from colonies in a plague-free region (South Dakota) and two plague-endemic regions (Colorado and Texas) were chal
Assessment of a recombinant F1-V fusion protein vaccine intended to protect Canada lynx (Lynx canadensis) from plague
As part of an ongoing restoration program in Colorado, USA, we evaluated adverse reactions and seroconversion in captive Canada lynx (Lynx canadensis) after vaccination with a recombinant F1-V fusion protein vaccine against Yersinia pestis, the bacterium that causes plague. Ten adult female lynx received the F1-V vaccine; 10 source- and age-matched lynx remained unvaccinated as controls. All of th
Authors
Lisa L. Wolfe, Tanya M. Shenk, Bradford Powell, Tonie E. Rocke
Population differences in host immune factors may influence survival of Gunnison's prairie dogs (Cynomys Gunnisoni) during plague outbreaks
Over the past 40 yr, epizootics of plague (Yersinia pestis) in northern Arizona have reduced populations of the Gunnison’s prairie dog (Cynomys gunnisoni), with the exception of a large population found in the Aubrey Valley (AV). To examine potential mechanisms accounting for their survival, we collected prairie dog serum samples in 2005–2006 from AV and a neighboring population near Seligman (SE)
Authors
Joseph D. Busch, Roger Van Andel, Jennifer Cordova, Rebecca E. Colman, Paul Keim, Tonie E. Rocke, Jeff G. Leid, William E. Van Pelt, David M. Wagner
Antigenic profiling of Yersinia pestis infection in the Wyoming coyote (Canis latrans)
Although Yersinia pestis is classified as a "high-virulence" pathogen, some host species are variably susceptible to disease. Coyotes (Canis latrans) exhibit mild, if any, symptoms during infection, but antibody production occurs postinfection. This immune response has been reported to be against the F1 capsule, although little subsequent characterization has been conducted. To further define the
Authors
G. Vernati, W.H. Edwards, T.E. Rocke, S.F. Little, G.P. Andrews
Degradation of the disease-associated prion protein by a serine protease from lichens
The disease-associated prion protein (PrP(TSE)), the probable etiological agent of the transmissible spongiform encephalopathies (TSEs), is resistant to degradation and can persist in the environment. Lichens, mutualistic symbioses containing fungi, algae, bacteria and occasionally cyanobacteria, are ubiquitous in the environment and have evolved unique biological activities allowing their surviva
Authors
C.J. Johnson, J. P. Bennett, S.M. Biro, J.C. Duque-Velasquez, C.M. Rodriguez, R. A. Bessen, T.E. Rocke
Degradation of the disease-associated prion protein by a serine protease from lichens.
The disease-associated prion protein (PrPTSE), the probable etiological agent of the transmissible spongiform encephalopathies (TSEs), is resistant to degradation and can persist in the environment. Lichens, mutualistic symbioses containing fungi, algae, bacteria and occasionally cyanobacteria, are ubiquitous in the environment and have evolved unique biological activities allowing their survival
Authors
Christopher J. Johnson, James P. Bennett, S.M. Biro, J. C. Duque-Velasquez, Cynthia M. Rodriguez, R. A. Bessen, Tonie E. Rocke
Population differences in host immune factors may influence survival of Gunnison's prairie dogs (Cynomys gunnisoni) during plague outbreaks
Over the past 40 yr, epizootics of plague (Yersinia pestis) in northern Arizona have reduced populations of the Gunnison's prairie dog (Cynomys gunnisoni), with the exception of a large population found in the Aubrey Valley (AV). To examine potential mechanisms accounting for their survival, we collected prairie dog serum samples in 2005-2006 from AV and a neighboring population near Seligman (SE)
Authors
J.D. Busch, Andel R. van, J. Cordova, Rebecca E. Colman, P. Keim, Tonie E. Rocke, Jeff G. Leid, W.E. van Pelt, D.M. Wagner
Use of Rhodamine B as a biomarker for oral plague vaccination of prairie dogs
Oral vaccination against Yersinia pestis could provide a feasible approach for controlling plague in prairie dogs (Cynomys spp.) for conservation and public health purposes. Biomarkers are useful in wildlife vaccination programs to demonstrate exposure to vaccine baits. Rhodamine B (RB) was tested as a potential biomarker for oral plague vaccination because it allows nonlethal sampling of animals
Authors
Julia Rodriguez-Ramos Fernandez, Tonie E. Rocke
Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus)
Baits containing recombinant raccoon poxvirus (RCN) expressing plague antigens (fraction 1 [F1] and a truncated form of the V protein-V307) were offered for voluntary consumption several times over the course of several months to a group of 16 black-tailed prairie dogs (Cynomys ludovicianus). For comparison, another group of prairie dogs (n = 12) was injected subcutaneously (SC) (prime and boost)
Authors
Tonie E. Rocke, Nicola Pussini, Susan Smith, Judy L. Williamson, Bradford Powell, Jorge E. Osorio
Enzootic plague reduces black-footed ferret (Mustela nigripes) survival in Montana
Black-footed ferrets (Mustela nigripes) require extensive prairie dog colonies (Cynomys spp.) to provide habitat and prey. Epizootic plague kills both prairie dogs and ferrets and is a major factor limiting recovery of the highly endangered ferret. In addition to epizootics, we hypothesized that enzootic plague, that is, presence of disease-causing Yersinia pestis without any noticeable prairie do
Authors
Marc R. Matchett, Dean E. Biggins, Valerie Carlson, Bradford Powell, Tonie E. Rocke