Immunomodulation

About the Research The Photomicroscopy and Flow Cytometry Core Technology Team (CTT) as part of the Environmental Health Program works to develop and apply biomarkers to evaluate the potential impacts of environmental contaminants at cellular and molecular levels. Because molecular and biochemical responses of cells are preceded by chemical changes in nuclei, cytoplasm, membranes, and...

About the Research The Functional and Molecular Bioassay Core Technology Team (CTT) as part of the Environmental Health Program utilizes reporter assays, quantitative gene expression analyses, and high-throughput sequencing methods to produce functional endpoints across a broad scope of environmental topics and sample matrices.

The team is determining the movement and behavior of per- and poly-fluoroalkyl substances (PFAS) from their sources in the environment, as they move through exposure pathways in ecosystems including watersheds and aquifers, their incorporation into food webs, and molecular to population scale effects on fish and wildlife. These studies are accomplished at a variety of spatial scales from regional...

The Immunomodulation Integrated Science Team focuses on contaminant and pathogen exposures in the environment that might influence the immune systems of wildlife and the connection to their shared environment with humans. In collaboration with public-health officials, the Team also addresses potential human-health risks stemming from similar exposures. If actual risks are identified, this Team...

Science from the U.S. Geological Survey (USGS) and other entities has shown that a mixture of natural and synthetic estrogens and other similar chemicals are discharged from wastewater treatment plants (WWTPs) to streams and rivers.

Adult frog exposure to pesticides in aquatic and terrestrial habitats was quantified using a novel combination of radio telemetry and passive sampling techniques to better understand factors affecting frog health and survival in agricultural landscapes.

Microbiologists at the Michigan Bacteriological Research Laboratory (MI-BaRL) use a wide array of traditional and modern molecular approaches to evaluate microbial pathogens and antimicrobial resistance pathways in the environment.

About the Research The Environmental Chemistry Laboratory Core Technology Team (CTT) as part of the Environmental Health Program develops and applies innovative methods of sampling and analysis to answer critical questions about the occurrence, distribution, fate and transport, and biological exposure of chemical in all environmental matrices (water, air, tissues, sediments, and others).

The Chesapeake Bay is the largest estuary in the United States and provides critical resources to fish, wildlife and people. For more than a decade, recreational fish species have been plagued with skin lesions and intersex conditions (the presence of male and female sex characteristics in the same fish) that biologists attributed to exposures to endocrine disrupting chemicals (EDCs)...