Sara J Oyler-McCance, PhD
Dr. Sara Oyler-McCance is a Supervisory Research Geneticist and Branch Chief for the Ecosystem and Organismal Ecology Branch at the Fort Collins Science Center. She is a conservation geneticist studying a wide variety of taxa.
The Molecular Ecology Lab

The FORT Molecular Ecology Laboratory applies genetic and genomic technologies to address a variety of complex questions and conservation issues facing the management of fish and wildlife resources. Together with partners, they design and implement studies to document genetic diversity and the distribution of genetic variation among individuals, populations, and species.
Highlighted Research
- Genome-wide adaptive divergence and conservation translocation
- Genetic connectivity in the Arizona toad (Anaxyrus microscaphus)
- Using fecal DNA to estimate feral horse population size
- A genetic warning system for a wildlife monitoring framework
- Genetic insights into mating strategies of the American black swift
- The transformative impact of genomics on sage-grouse conservation and management
- Environmental DNA (eDNA) sampling improves estimates of invasive Burmese pythons
As a research geneticist and director of the Fort Collins Science Center’s Molecular Ecology Lab, Dr. Oyler-McCance’s research is dedicated to the application and advancement of genetic theory and techniques to address a variety of complex questions and conservation issues facing the management of the Nation's fish and wildlife resources and their habitats. Some of her research involves questions concerning species of conservation concern, yet some involves detection of invasive species. She uses genetic and genomic methods to investigate connectivity and to identify adaptive genetic diversity, both of which are important for ensuring persistence of species in changing landscapes. She uses state-of-the-art technology (for example, novel environmental DNA applications) to detect important invasive species. Her work also explores how to optimally manage the genetic diversity within a species (for example, through translocations) and how to best inventory what species are present and the state of species well-being, persistence, or risk (that is, population size, levels of genetic diversity).
Professional Experience
March 2023 - Present: Branch Chief, Ecosystem and Organismal Ecology Branch, US Geological Survey, Fort Collins Science Center, Fort Collins, Colorado
February 1999 - Present: Research Geneticist, US Geological Survey, Fort Collins Science Center, Fort Collins, Colorado
Education and Certifications
Ph.D. in Fish, Wildlife, and Conservation Biology, Colorado State University, 1999
M.S. in Wildlife Biology, University of Maine, 1993
B.S. in Biology, University of Michigan, 1991
Affiliations and Memberships*
Affiliate Faculty, Ecosystem Science and Sustainability, Colorado State University
Affiliate Faculty, Fish Wildlife and Conservation Biology, Colorado State University
Affiliate Faculty, Graduate Degree Program in Ecology, Colorado State University
Affiliate Faculty, Department of Integrative Biology, University of Colorado, Denver
Science and Products
Quantifying functional connectivity: The role of breeding habitat, abundance, and landscape features on range‐wide gene flow in sage‐grouse
Genetic mark–recapture improves estimates of maternity colony size for Indiana bats
The genetic network of greater sage-grouse: Range-wide identification of keystone hubs of connectivity
Long-term persistence of horse fecal DNA in the environment makes equids particularly good candidates for non-invasive sampling
Sage grouse
Extensive shared polymorphism at non-MHC immune genes in recently diverged North American prairie grouse
Developing approaches for linear mixed modeling in landscape genetics through landscape-directed dispersal simulations
Polygamy slows down population divergence in shorebirds
Integration of genetic and demographic data to assess population risk in a continuously distributed species
Latent spatial models and sampling design for landscape genetics
Critical considerations for the application of environmental DNA methods to detect aquatic species
Differential influences of local subpopulations on regional diversity and differentiation for greater sage-grouse (Centrocercus urophasianus)
Non-USGS Publications**
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
Science and Products
Quantifying functional connectivity: The role of breeding habitat, abundance, and landscape features on range‐wide gene flow in sage‐grouse
Genetic mark–recapture improves estimates of maternity colony size for Indiana bats
The genetic network of greater sage-grouse: Range-wide identification of keystone hubs of connectivity
Long-term persistence of horse fecal DNA in the environment makes equids particularly good candidates for non-invasive sampling
Sage grouse
Extensive shared polymorphism at non-MHC immune genes in recently diverged North American prairie grouse
Developing approaches for linear mixed modeling in landscape genetics through landscape-directed dispersal simulations
Polygamy slows down population divergence in shorebirds
Integration of genetic and demographic data to assess population risk in a continuously distributed species
Latent spatial models and sampling design for landscape genetics
Critical considerations for the application of environmental DNA methods to detect aquatic species
Differential influences of local subpopulations on regional diversity and differentiation for greater sage-grouse (Centrocercus urophasianus)
Non-USGS Publications**
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
*Disclaimer: Listing outside positions with professional scientific organizations on this Staff Profile are for informational purposes only and do not constitute an endorsement of those professional scientific organizations or their activities by the USGS, Department of the Interior, or U.S. Government