Publications
Below is a list of available Fish Health Program peer reviewed and published science.
Filter Total Items: 323
Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses
The aquaculture industry is growing rapidly to meet the needs for global protein consumption. Viral diseases in aquaculture are quite challenging due to lack of treatment options as well as limited injection-delivery vaccines, which are costly. Thus, water-immersion antiviral treatments are highly desirable. This study focused on broad-spectrum, light-activated antivirals that target the viral mem
Authors
Bethany F. Balmer, Rodman G. Getchell, Rachel L. Powers, Jihye Lee, Tinghu Zhang, Michael E. Jung, Maureen K. Purcell, Kevin Snekvik, Hector C. Aguilar
Insight into infectious hematopoietic necrosis virus (IHNV) in Chinese rainbow trout aquaculture from virus isolated from 7 provinces in 2010–2014
The aquatic rhabdovirus infectious hematopoietic necrosis virus (IHNV) currently causes substantial fish losses in Chinese coldwater aquaculture. While IHNV was first reported in China in 1985 and has since undergone considerable spread, little is known about the underlying epidemiological patterns like introduction sources and transmission routes. In this study, we examined epidemiological and ph
Authors
Peng Jia, Rachel B. Breyta, Qing Li, Xu Qian, Bing Wu, Wei Zheng, Zhiqing Wen, Ying Liu, Gael Kurath, Qunyi Hua, Ningyi Jin, Hong Liu
Herring Disease Program, February 1, 2018 - January 31, 2019
This report describes our laboratory and field results for the period February 1, 2018-January 31, 2019.
Authors
Paul Hershberger, Maureen Purcell
An epidemiological model of virus transmission in salmonid fishes of the Columbia River Basin
We have developed a dynamic epidemiological model informed by records of viral presence and genotypes to evaluate potential transmission routes maintaining a viral pathogen in economically and culturally important anadromous fish populations. In the Columbia River Basin, infectious hematopoietic necrosis virus (IHNV) causes severe disease, predominantly in juvenile steelhead trout (Oncorhynchus my
Authors
Paige F. B. Ferguson, Rachel Breyta, Ilana L. Brito, Gael Kurath, Shannon L. LaDeau
Development and characterization of two cell lines from gills of Atlantic salmon
Gill disease in Atlantic salmon, Salmo salar L., causes big losses in the salmon farming industry. Until now, tools to cultivate microorganisms causing gill disease and models to study the gill responses have been lacking. Here we describe the establishment and characterization of two cell lines from the gills of Atlantic salmon. Atlantic salmon gill cell ASG-10 consisted of cells staining for cyt
Authors
Mona C. Gjessing, Maria Aamelfot, William N. Batts, Sylvie L. Benestad, Ole B. Dale, Even Thoen, Simon C. Weli, James R. Winton
Virulence of a chimeric recombinant infectious haematopoietic necrosis virus expressing the spring viraemia of carp virus glycoprotein in salmonid and cyprinid fish
Infectious haematopoietic necrosis virus (IHNV) and spring viraemia of carp virus (SVCV) are both rhabdoviruses of fish, listed as notifiable disease agents by the World Organization for Animal Health. Recombinant rhabdoviruses with heterologous gene substitutions have been engineered to study genetic determinants and assess the potential of these recombinant viruses for vaccine development. A rec
Authors
Eveline Emmenegger, Stéphane Biacchesi, Emilie Mérour, Jolene. A Glenn, Alexander D. Palmer, Michel Brémont, Gael Kurath
Molecular testing of adult Pacific salmon and trout (Oncorhynchus spp.) for several RNA viruses demonstrates widespread distribution of piscine orthoreovirus in Alaska and Washington
This research was initiated in conjunction with a systematic, multiagency surveillance effort in the United States (U.S.) in response to reported findings of infectious salmon anaemia virus (ISAV) RNA in British Columbia, Canada. In the systematic surveillance study reported in a companion paper, tissues from various salmonids taken from Washington and Alaska were surveyed for ISAV RNA using the U
Authors
Maureen K. Purcell, Rachel L. Thompson, Joy Evered, John Kerwin, Ted R. Meyers, Bruce Stewart, James Winton
A systematic surveillance programme for infectious salmon anaemia virus supports its absence in the Pacific Northwest of the United States
In response to reported findings of infectious salmon anaemia virus (ISAV) in British Columbia (BC), Canada, in 2011, U.S. national, state and tribal fisheries managers and fish health specialists developed and implemented a collaborative ISAV surveillance plan for the Pacific Northwest region of the United States. Accordingly, over a 3-1/2-year period, 4,962 salmonids were sampled and successfull
Authors
Lori L. Gustafson, Lynn H. Creekmore, Kevin R. Snekvik, Jayde A. Ferguson, Janet V. Warg, Marilyn Blair, Theodore R. Meyers, Bruce Stewart, Kenneth I. Warheit, John Kerwin, Andrew E. Goodwin, Linda D. Rhodes, Janet E. Whaley, Maureen K. Purcell, Collette Bentz, Desiree Shasa, Joel Bader, James R. Winton
Observations and first reports of saprolegniosis in Aanaakłiq, broad whitefish (Coregonus nasus), from the Colville River near Nuiqsut, Alaska
We report the first confirmed cases (2013–2016) of saprolegniosis caused by water mold from the genus Saprolegnia in Aanaakłiq, broad whitefish (Coregonus nasus), from the Colville River near Nuiqsut, Alaska. While this mold is known to be worldwide, these instances represent the first cases in Nuiqsut and only the second instance on a single fish on the North Slope, occurring in 1980. We describe
Authors
Todd L. Sformo, Billy Adams, John C. Seigle, Jayde A. Ferguson, Maureen K. Purcell, Raphaela Stimmelmayr, Joseph H. Welch, Leah M. Ellis, Jason C. Leppi, John C. George
Vaccine effects on heterogeneity in susceptibility and implications for population health management
Heterogeneity in host susceptibility is a key determinant of infectious disease dynamics but is rarely accounted for in assessment of disease control measures. Understanding how susceptibility is distributed in populations, and how control measures change this distribution, is integral to predicting the course of epidemics with and without interventions. Using multiple experimental and modeling ap
Authors
Kate E. Langwig, Andrew R. Wargo, Darbi R. Jones, Jessie R. Viss, Barbara J. Rutan, Nicholas A. Egan, Pedro Sá-Guimarães, Min Sun Kim, Gael Kurath, M. Gabriela M. Gomes, Marc Lipsitch
Complete sequences of 4 viral hemorrhagic septicemia virus IVb isolates and their virulence in northern pike fry
Four viral hemorrhagic septicemia virus (VHSV) genotype IVb isolates were sequenced, their genetic variation explored, and comparative virulence assayed with experimental infections of northern pike Esox lucius fry. In addition to the type strain MI03, the complete 11183 bp genome of the first round goby Neogobius melanostomus isolate from the St. Lawrence River, and the 2013 and 2014 isolates fro
Authors
Rodman G. Getchell, Emily R. Cornwell, Steven Bogdanowicz, Jose Andres, William N. Batts, Gael Kurath, Rachel Breyta, Joanna G. Choi, John M. Farrell, Paul R. Bowser
A effective DNA vaccine against diverse genotype J infectious hematopoietic necrosis virus strains prevalent in China
Infectious hematopoietic necrosis virus (IHNV) is the most important pathogen threatening the aquaculture of salmonid fish in China. In this study, a DNA vaccine, designated pIHNch-G, was constructed with the glycoprotein (G) gene of a Chinese IHNV isolate SD-12 (also called Sn1203) of genotype J. The minimal dose of vaccine required, the expression of the Mx-1 gene in the muscle (vaccine delivery
Authors
Liming Xu, Jingzhuang Zhao, Miao Liu, Gael Kurath, Guangming Ren, Scott E. LaPatra, Jiasheng Yin, Hongbai Liu, Jian Feng, Tongyan Lu