Sara J Oyler-McCance, PhD
Dr. Sara Oyler-McCance is a Supervisory Research Geneticist and Branch Chief for the Ecosystem and Organismal Ecology Branch at the Fort Collins Science Center. She is a conservation geneticist studying a wide variety of taxa.
The Molecular Ecology Lab

The FORT Molecular Ecology Laboratory applies genetic and genomic technologies to address a variety of complex questions and conservation issues facing the management of fish and wildlife resources. Together with partners, they design and implement studies to document genetic diversity and the distribution of genetic variation among individuals, populations, and species.
Highlighted Research
- Genome-wide adaptive divergence and conservation translocation
- Genetic connectivity in the Arizona toad (Anaxyrus microscaphus)
- Using fecal DNA to estimate feral horse population size
- A genetic warning system for a wildlife monitoring framework
- Genetic insights into mating strategies of the American black swift
- The transformative impact of genomics on sage-grouse conservation and management
- Environmental DNA (eDNA) sampling improves estimates of invasive Burmese pythons
As a research geneticist and director of the Fort Collins Science Center’s Molecular Ecology Lab, Dr. Oyler-McCance’s research is dedicated to the application and advancement of genetic theory and techniques to address a variety of complex questions and conservation issues facing the management of the Nation's fish and wildlife resources and their habitats. Some of her research involves questions concerning species of conservation concern, yet some involves detection of invasive species. She uses genetic and genomic methods to investigate connectivity and to identify adaptive genetic diversity, both of which are important for ensuring persistence of species in changing landscapes. She uses state-of-the-art technology (for example, novel environmental DNA applications) to detect important invasive species. Her work also explores how to optimally manage the genetic diversity within a species (for example, through translocations) and how to best inventory what species are present and the state of species well-being, persistence, or risk (that is, population size, levels of genetic diversity).
Professional Experience
March 2023 - Present: Branch Chief, Ecosystem and Organismal Ecology Branch, US Geological Survey, Fort Collins Science Center, Fort Collins, Colorado
February 1999 - Present: Research Geneticist, US Geological Survey, Fort Collins Science Center, Fort Collins, Colorado
Education and Certifications
Ph.D. in Fish, Wildlife, and Conservation Biology, Colorado State University, 1999
M.S. in Wildlife Biology, University of Maine, 1993
B.S. in Biology, University of Michigan, 1991
Affiliations and Memberships*
Affiliate Faculty, Ecosystem Science and Sustainability, Colorado State University
Affiliate Faculty, Fish Wildlife and Conservation Biology, Colorado State University
Affiliate Faculty, Graduate Degree Program in Ecology, Colorado State University
Affiliate Faculty, Department of Integrative Biology, University of Colorado, Denver
Science and Products
An empirical comparison of population genetic analyses using microsatellite and SNP data for a species of conservation concern
The transformative impact of genomics on sage-grouse conservation and management
Characterizing range-wide population divergence in an alpine-endemic bird: A comparison of genetic and genomic approaches
Genetic mark‐recapture analysis of winter faecal pellets allows estimation of population size in Sage Grouse Centrocercus urophasianus
Signatures of adaptive divergence among populations of an avian species of conservation
Conservation genomics in the sagebrush sea: Population divergence, demographic history, and local adaptation in sage-grouse (Centrocercus spp.)
Mismatches between breeding phenology and resource abundance of resident alpine ptarmigan negatively affect chick survival
Development of microsatellite loci for two New World vultures (Cathartidae)
Evaluation of a Chicken 600K SNP genotyping array in non-model species of grouse
Evaluation of genetic change from translocation among Gunnison Sage-Grouse (Centrocercus minimus) populations
Post-release breeding of translocated sharp-tailed grouse and an absence of artificial insemination effects
An experimental comparison of composite and grab sampling of stream water for metagenetic analysis of environmental DNA
Non-USGS Publications**
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
Science and Products
An empirical comparison of population genetic analyses using microsatellite and SNP data for a species of conservation concern
The transformative impact of genomics on sage-grouse conservation and management
Characterizing range-wide population divergence in an alpine-endemic bird: A comparison of genetic and genomic approaches
Genetic mark‐recapture analysis of winter faecal pellets allows estimation of population size in Sage Grouse Centrocercus urophasianus
Signatures of adaptive divergence among populations of an avian species of conservation
Conservation genomics in the sagebrush sea: Population divergence, demographic history, and local adaptation in sage-grouse (Centrocercus spp.)
Mismatches between breeding phenology and resource abundance of resident alpine ptarmigan negatively affect chick survival
Development of microsatellite loci for two New World vultures (Cathartidae)
Evaluation of a Chicken 600K SNP genotyping array in non-model species of grouse
Evaluation of genetic change from translocation among Gunnison Sage-Grouse (Centrocercus minimus) populations
Post-release breeding of translocated sharp-tailed grouse and an absence of artificial insemination effects
An experimental comparison of composite and grab sampling of stream water for metagenetic analysis of environmental DNA
Non-USGS Publications**
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
*Disclaimer: Listing outside positions with professional scientific organizations on this Staff Profile are for informational purposes only and do not constitute an endorsement of those professional scientific organizations or their activities by the USGS, Department of the Interior, or U.S. Government