Publications
Dive into our publications and explore the science from the Environmental Health Program (Toxic Substances Hydrology and Contaminant Biology).
Filter Total Items: 4094
Untargeted lipidomics for determining cellular and sub-cellular responses in Zebrafish (Danio rerio) liver cells following exposure to complex mixtures in U.S. streams
Surface waters often contain a variety of chemical contaminants potentially capable of producing adverse outcomes in both humans and wildlife due to impacts from industrial, urban, and agricultural activity. Here, we report the results of a zebrafish liver (ZFL) cell-based lipidomics approach to assess the potential ecotoxicological effects of complex contaminant mixtures using water collected fro
Authors
Huajun Zhen, Quincy Teng, Jonathan D Mosley, Timothy W. Collette, Yang Yue, Paul M. Bradley, Drew R. Ekman
Perfluoroalkyl substances in plasma of smallmouth bass from the Chesapeake Bay Watershed
Smallmouth bass Micropterus dolomieu is an economically important sportfish and within the Chesapeake Bay watershed has experienced a high prevalence of external lesions, infectious disease, mortality events, reproductive endocrine disruption and population declines. To date, no clear or consistent associations with contaminants measured in fish tissue or surface water have been found. Therefore,
Authors
Vicki S. Blazer, Stephanie Gordon, Heather L. Walsh, Cheyenne R. Smith
Satellite remote sensing to assess cyanobacterial bloom frequency across the United States at multiple spatial scales
Cyanobacterial blooms can have negative effects on human health and local ecosystems. Field monitoring of cyanobacterial blooms can be costly, but satellite remote sensing has shown utility for more efficient spatial and temporal monitoring across the United States. Here, satellite imagery was used to assess the annual frequency of surface cyanobacterial blooms, defined for each satellite pixel as
Authors
Megan M. Coffer, Blake Schaeffer, Wilson B. Salls, Erin Urquhart, Keith Loftin, Richard P. Stumpf, P. Jeremy Werdell, John A. Darling
Arsenic in petroleum-contaminated groundwater near Bemidji, Minnesota is predicted to persist for centuries
We used a reactive transport model to investigate the cycling of geogenic arsenic (As) in a petroleum-contaminated aquifer. We simulated As mobilization and sequestration using surface complexation reactions with Fe(OH)3 during petroleum biodegradation coupled with Fe-reduction. Model results predict that dissolved As in the plume will exceed the U.S. and EU 10 µg/L drinking water standard for ~40
Authors
Brady A. Ziegler, G.-H. Crystal Ng, Isabelle M. Cozzarelli, Aubrey J. Dunshee, Madeline E. Schreiber
Identifying chemicals and mixtures of potential biological concern detected in passive samplers from Great Lakes tributaries using high-throughput data and biological pathways
Waterborne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs) and polar organic chemical integrative samplers (POCIS). A risk-based screening approach was used to prioritize chemicals and chemical mixtures, identify sites at greatest risk for biological impacts, and identify potential hazards to monitor at those
Authors
David Alvarez, Steven R. Corsi, Laura A. DeCicco, Daniel L. Villeneuve, Austin K. Baldwin
Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA
A pilot-scale expanded target assessment of mixtures of inorganic and organic contaminants in point-of-consumption drinking water (tapwater, TW) was conducted in Puerto Rico (PR) to continue to inform TW exposures and corresponding estimations of cumulative human-health risks across the US. In August 2018, a spatial synoptic pilot assessment of than 524 organic, 37 inorganic, and select microbiolo
Authors
Paul M. Bradley, Ingrid Y. Padilla, Kristin M. Romanok, Kelly Smalling, Michael J. Focazio, Sara E. Breitmeyer, Mary C. Cardon, Justin M. Conley, Nicola Evans, Carrie E Givens, James L. Gray, L. Earl Gray, Phillip C. Hartig, Michelle Hladik, Christopher P. Higgins, Luke R. Iwanowicz, Rachael F. Lane, Keith Loftin, R. Blaine McCleskey, Carrie A. McDonough, Elizabeth Medlock-Kakaley, Shannon M. Meppelink, Christopher P. Weis, Vickie S. Wilson
Cross-ecosystem fluxes of pesticides from prairie wetlands mediated by aquatic insect emergence: Implications for terrestrial insectivores
Contaminants alter the quantity and quality of insect prey available to terrestrial insectivores. In agricultural regions, the quantity of aquatic insects emerging from freshwaters can be impacted by insecticides originating from surrounding croplands. We hypothesized that, in such regions, adult aquatic insects could also act as vectors of pesticide transfer to terrestrial food webs. To estimate
Authors
Johanna M. Kraus, Kathryn Kuivila, Michelle Hladik, Neil Shook, David M. Mushet, Kelen Dowdy, Rachel Harrington
Trends in agricultural triazole fungicide sse in the United States, 1992–2016 and possible implications for antifungal-resistant fungi in human disease
Background:The fungus Aspergillus fumigatus (A. fumigatus) is the leading cause of invasive mold infections, which cause severe disease and death in immunocompromised people. Use of triazole antifungal medications in recent decades has improved patient survival; however, triazole-resistant infections have become common in parts of Europe and are emerging in the United States. Triazoles are also a
Authors
Mitsuru Toda, Karlyn D. Beer, Kathryn Kuivila, Tom M. Chiller, Brendan R. Jackson
Field-level exposure of bumble bees to fungicides applied to a commercial cherry orchard
Bumble bees, Bombus spp. (Apidae), are important native pollinators; however, populations of some species are declining in North America and agricultural chemicals are a potential cause. Fungicides are generally not highly toxic to bees, but little is known about sublethal or synergistic effects. This study evaluates bumble bee exposure to fungicides by quantifying concentrations of boscalid and p
Authors
Kathryn M. Kuivila, Houston Judd, Michelle Hladik, James P. Strange
Emerging investigator series: Municipal wastewater as a year-round point source of neonicotinoid insecticides that persist in an effluent-dominated stream
Neonicotinoids in aquatic systems have been predominantly associated with agriculture, but some are increasingly being linked to municipal wastewater. Thus, the aim of this work was to understand the municipal wastewater contribution to neonicotinoids in a representative, characterized effluent-dominated temperate-region stream. Our approach was to quantify the spatiotemporal concentrations of imi
Authors
Danielle T. Webb, Hui Zhi, Dana W. Kolpin, Rebecca D. Klaper, Luke R. Iwanowicz, Gregory H. LeFevre
The role of behavioral ecotoxicology in environmental protection
For decades, we have known that chemicals affect human and wildlife behavior. Moreover, due to recent technological and computational advances, scientists are now increasingly aware that a wide variety of contaminants and other environmental stressors adversely affect organismal behavior and subsequent ecological outcomes in terrestrial and aquatic ecosystems. There is also a groundswell of concer
Authors
Alex T. Ford, Marlene Ågerstrand, Bryan W. Brooks, Joel Allen, Michael G. Bertram, Tomas Brodin, Zhichao Dang, Sabine Duquesne, René Sahm, Frauke Hoffmann, Henner Hollert, Stefanie Jacob, Nils Klüver, James M. Lazorchak, Mariana Ledesma, Steven D. Melvin, Silvia Mohr, Stephanie Padilla, Gregory G. Pyle, Stefan Scholz, Minna Saaristo, Els Smit, Jeffery Steevens, Sanne van den Berg, Werner Kloas, Bob B.M. Wong, Michael Ziegler, Gerd Maack
Prevalence of neonicotinoids and sulfoxaflor in alluvial aquifers in a high corn and soybean producing region of the Midwestern United States
Neonicotinoids have been previously detected in Iowa surface waters, but less is known regarding their occurrence in groundwater. To help fill this research gap, a groundwater study was conducted in eastern Iowa and southeastern Minnesota, a corn and soybean producing area with known heavy neonicotinoid use. Neonicotinoids were studied in alluvial aquifers, a hydrogeologic setting known to be vuln
Authors
D.A. Thompson, Dana W. Kolpin, Michelle Hladik, Kimberlee K. Barnes, J.D. Vargo, R.W. Field